Cohort coordinator: Marie Zins
Key data: 220,000 adult volunteers
This is France’s largest cohort, comprising a random sample of 220,000 adult volunteers affiliated to the Social Security system. Participants are between 18 and 69 years old at the time of inclusion between 2012 and 2019. CONSTANCES contributes to many areas of research: risk factors and natural history of diseases, early biomarkers of disease, long-term adverse drug reactions, care trajectories or epidemiological surveillance. It studies the impact of environmental and occupational exposures on health. Participants are monitored by medical examinations and questionnaires.
Cohort coordinator: Gianluca Severi
Key data: 200,000 volunteers on several generations
The E3N-Generations study is conducted by Inserm, the French National Institute for Health and Medical Research, and aims to follow families over three generations, in order to gather essential data for epidemiological and public health research. Nearly 200,000 participants – women, children and grandchildren – are included in this cohort. The women are aged between 40 and 65, and have been followed since 1990. The study was selected by the National Research Agency for the “ Investments for the Future ” program in 2011. This cohort studies the links between lifestyle, cancer and other pathologies, particularly chronic ones. Participants are monitored using online questionnaires, biological samples and innovative tools (e.g. pollution sensors, connected bracelets).
Cohort coordinator: Mathilde Touvier
Key data: 172,000 adult volunteers
The aim of this study is to identify nutrition-related risk or protective factors for diseases that are major public health problems today, in order to establish nutritional recommendations aimed at preventing these diseases and improving the health of populations. It is made up of 172,000 adult volunteers monitored via the NutriNet-Santé website on the basis of questionnaires.
Cohort coordinator: Cécile Chevrier
Key data: 3,500 mother-children volunteers
The PELAGIE study (Endocrine Disruptors: Longitudinal Study of Pregnancy, Infertility and Childhood Anomalies) was set up in response to concerns about the health of children and adolescents due to the presence of toxic compounds in our everyday environments. It involves monitoring some 3,500 mother-children since their birth in 2002 in Brittany. This follow-up is based on questionnaires. Sub-groups are monitored in greater depth for cognitive and psychological development, brain function, pubertal development and the environment in which they live.
Cohort coordinator: Barbara Heude
Key data: 2,002 young adults born in 2003
This is the first general cohort study in France to examine early pre- and post-natal determinants of child development and health. Its aim is to better establish the importance of early determinants on individual health, particularly in relation to the environmental factors that influence it during childhood and into adulthood. A total of 2,002 children born in 2003 have been tracked since birth by means of questionnaires, analyses of biological samples and clinical examinations. Mothers were recruited at the end of the first trimester of pregnancy in two maternity centers at the Nancy and Poitiers university hospitals.
Cohort coordinator: Marie-Aline Charles
Key data: 18,000 adolescents born in 2011
The aim of the Elfe study is to gain a better understanding of the factors (environment, family environment, living conditions, etc.) that can influence a child’s physical and psychological development, health and socialization. The cohort consists of 18,000 children born in 2011. Questionnaire interviews and biological sampling are carried out at different stages in the child’s life, in order to report on their development and evolution.